Aptasensors design considerations

With the advancement of biotechnology, aptamer-based sensors have received intense attention in both research and commercial worlds. This is driven by the advantages of small molecule size, chemical stability, and cost effectiveness of aptamers over the conventional analyte detection using antibodies. This paper explores the aptasensors from a designer perspective and discusses the aptasensor design considerations by giving an overview of surface functionalization techniques and the existing mechanisms used to detect biomolecular interactions. It also expounds the factors that influence the accuracy and sensitivity of aptasensors.