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Host cell remodelling and protein trafficking
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posted on 2013-01-01, 00:00 authored by Silvia Haase, H Bullen, S Charnaud, B Crabb, P Gilson, T de Koning WardInside their respective vertebrate hosts, Plasmodium spp spend most of their life residing within hepatocytes and erythrocytes, with large-scale infection of the latter responsible for the clinical symptoms associated with malaria. These parasites extensively remodel these host cells for a variety of purposes relating to both pathogenesis and maintaining growth. Remodelling of the erythrocytic stage has been most intensively studied in P. falciparum and is the subject of this chapter. To help remodel their hosts these parasites export hundreds of proteins into the erythrocytic compartment. This principally alters the architecture of the erythrocyte, rendering the host membrane more permeable to solutes and nutrients, and also increasing the rigidity and adhesiveness of the infected erythrocyte. Moreover, because erythrocytes lack a secretory apparatus, the parasite must also export many additional proteins to help traffic other proteins to their correct destination within the host cell. The functions of some of these exported proteins will be discussed as will recent progress that has been made in unravelling how exported proteins gain access to the host compartment.
History
Title of book
Malaria parasites : comparative genomics, evolution and molecular biologyChapter number
9Pagination
199 - 219Publisher
Caister Academic PressPlace of publication
[Wymondham, England]ISBN-13
9781908230072ISBN-10
190823007XLanguage
engPublication classification
B1 Book chapterCopyright notice
2013, Caister Academic PressExtent
11Editor/Contributor(s)
J Carlton, S Perkins, K DeitschUsage metrics
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No categories selectedKeywords
microbiologymedical microbiologymolecular microbiologygenomicsparasitologyScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyERYTHROCYTE SURFACE-ANTIGENHISTIDINE-RICH PROTEINRED-BLOOD-CELLSPLASMODIUM-FALCIPARUM PROTEINPARASITOPHOROUS VACUOLE MEMBRANERING-EXPORTED PROTEIN-1INFECTED ERYTHROCYTEMAURERS CLEFTSMALARIA VIRULENCEGENE FAMILY
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