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Formulation and simulation of a 3D mechanical model of embryos for microinjection
conference contribution
posted on 2013-01-01, 00:00 authored by Marzieh AsgariMarzieh Asgari, H Abdi, Chee Peng LimChee Peng Lim, Saeid NahavandiThe understanding of cell manipulation, for example in microinjection, requires an accurate model of the cells. Motivated by this important requirement, a 3D particlebased mechanical model is derived for simulating the deformation of the fish egg membrane and the corresponding cellular forces during microrobotic cell injection. The model is formulated based on the kinematic and dynamic of spring- damper configuration with multi-particle joints considering the visco-elastic fluidic properties. It simulates the indentation force feedback as well as cell visual deformation during microinjection. A preliminary simulation study is conducted with different parameter configurations. The results indicate that the proposed particle-based model is able to provide similar deformation profiles as observed from a real microinjection experiment of the zebrafish embryo published in the literature. As a generic modelling approach is adopted, the proposed model also has the potential in applications with different types of manipulation such as micropipette cell aspiration.
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Event
IEEE Systems, Man and Cybernetics. Conference (2013 : Manchester, England)Pagination
2219 - 2224Publisher
IEEELocation
Manchester, EnglandPlace of publication
Piscataway, N.J.Start date
2013-10-13End date
2013-10-16Language
engPublication classification
E1 Full written paper - refereedCopyright notice
2013, IEEETitle of proceedings
SMC 2013 : Proceedings of the 2013 IEEE International Conference on Systems, Man and CyberneticsUsage metrics
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