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Protein-fatty acid conjugate for self-assembled nanoparticles in drug delivery
Novel biocompatible protein-oleic acid conjugate was prepared to form self-assembled nanoparticles (NP) when exposed to an aqueous medium. The conjugation of protein-fatty acid was confirmed using FTIR and NMR. The physicochemical properties of NP were characterized by the experimental conditions such as pH, temperature and the amount of protein/fatty acid. The self-assembled NP had a uniformly spherical shape with particle size (150-200 nm) and showed good physical stability. This NP had no any potential cellular toxicity. Paclitaxel was chosen as model drug for anti-cancer effect using self-assembled NP. Drug release was controlled over an extended period of time. Furthermore, surface-modified NP using folic acid showed a higher cancer-cell killing effect as compared with Taxol®. The in vivo pharmacokinetic parameters and biodistribution of the NP containing paclitaxel also indicated longer blood circulation. © 2013 IFMBE.
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Volume
40 IFMBEPagination
301 - 303Publisher DOI
ISSN
1680-0737ISBN-13
9783642321825Publication classification
E1.1 Full written paper - refereedTitle of proceedings
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