czeczor-appdeficiency-2018.pdf (1.08 MB)
APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding
journal contribution
posted on 2018-06-01, 00:00 authored by Juliane Czeczor, Amanda Genders, Kathryn Aston-MourneyKathryn Aston-Mourney, Timothy ConnorTimothy Connor, Liam Hall, Kyoko Hasebe, Megan EllisMegan Ellis, Kirstie Anne De Jong, D C Henstridge, P J Meikle, M A Febbraio, Ken WalderKen Walder, Sean McgeeSean McgeeThe amyloid precursor protein (APP) generates a number of peptides when processed through different cleavage mechanisms, including the amyloid beta peptide that is implicated in the development of Alzheimer's disease. It is well established that APP via its cleaved peptides regulates aspects of neuronal metabolism. Emerging evidence suggests that amyloidogenic processing of APP can lead to altered systemic metabolism, similar to that observed in metabolic disease states. In the present study, we investigated the effect of APP deficiency on obesity-induced alterations in systemic metabolism. Compared with WT littermates, APP-deficient mice were resistant to diet-induced obesity, which was linked to higher energy expenditure and lipid oxidation throughout the dark phase and was associated with increased spontaneous physical activity. Consistent with this lean phenotype, APP-deficient mice fed a high-fat diet (HFD) had normal insulin tolerance. However, despite normal insulin action, these mice were glucose intolerant, similar to WT mice fed a HFD. This was associated with reduced plasma insulin in the early phase of the glucose tolerance test. Analysis of the pancreas showed that APP was required to maintain normal islet and β-cell mass under high fat feeding conditions. These studies show that, in addition to regulating aspects of neuronal metabolism, APP is an important regulator of whole body energy expenditure and glucose homeostasis under high fat feeding conditions.
History
Journal
Journal of endocrinologyVolume
237Issue
3Pagination
311 - 322Publisher
BioscientificaLocation
Bradley Stok, Eng.Publisher DOI
eISSN
1479-6805Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2018, Society for EndocrinologyUsage metrics
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