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A comparison study of cerebral protection using Ginkgo biloba extract and Losartan on stroked rats

journal contribution
posted on 2006-05-01, 00:00 authored by K Loh, L Low, W Wong, S Zhou, S Huang, R Silva, Wei DuanWei Duan, W Chou, Y Zhu
It has been well documented that oxidative stress is involved in stroke. Currently, many neuroprotective strategies have been targeted at molecules that are able to act as an oxidant to intervene with free-radical mediated apoptosis in the ischemic penumbra. In particular, natural products which contain antioxidant properties have undoubtedly efficacious for stroke treatment. In the current study, therapeutic effects of Ginkgo biloba extract (EGb) against cerebral protection in Wistar rats underwent middle cerebral artery occlusion (MCAO) was evaluated. A comparison study was conducted by using Losartan, an antihypertensive drug. Gene expression levels of pro-apoptotic genes (AT2 receptor, Fas, Bax and Bcl-xS) have shown to have significant reduction by EGb- and Losartan-treated groups as compared to vehicle group. Significant reduction of immunoreactivity of protein production of these genes, together with least nuclear green fluorescence observed in TUNEL, EGb, as an antioxidant drug, is concluded to have potent and promising therapeutic effect for stroke treatment.

History

Journal

Neuroscienceletters

Volume

398

Issue

1-2

Pagination

28 - 33

Publisher

Elsvier Ireland Ltd

Location

Limerick, Ireland

ISSN

0304-3940

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2005, Elsvier Ireland Ltd