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A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: Protocol and rationale of the Take a STAND for Health study

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posted on 2020-01-01, 00:00 authored by A J Pinto, T Peçanha, K Meireles, F B Benatti, K Bonfiglioli, A L De Sá Pinto, F R Lima, R M R Pereira, M C C Irigoyen, J E Turner, J P Kirwan, N Owen, David DunstanDavid Dunstan, H Roschel, B Gualano
Background: Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reducing sedentary time could be of novel therapeutic relevance. However, studies addressing this topic remain scarce. We aim to investigate the feasibility and efficacy of a newly developed intervention focused on reducing sedentary time, and potential clinical, physiological, metabolic and molecular effects in rheumatoid arthritis. Methods: The Take a STAND for Health study is a 4-month, parallel-group, randomized controlled trial, in which postmenopausal patients with rheumatoid arthritis will set individually tailored, progressive goals to replace their sedentary time with standing and light-intensity activities. Patients will be recruited from the Clinical Hospital (School of Medicine, University of Sao Paulo) and will be assessed at baseline and after a 4-month follow up. Outcomes will include objectively measured sedentary behavior (primary outcome) and physical activity levels, clinical parameters, anthropometric parameters and body composition; aerobic fitness, muscle function, blood pressure, cardiovascular autonomic function, vascular function and structure, health-related quality of life, and food intake. Blood and muscle samples will be collected for assessing potential mechanisms, through targeted and non-targeted approaches. Discussion: Findings will be of scientific and clinical relevance with the potential to inform new prescriptions focused on reducing sedentary behavior, a modifiable risk factor that thus far has been overlooked in patients with rheumatoid arthritis.

History

Journal

Trials

Volume

21

Pagination

1 - 13

Publisher

BioMed Central

Location

London, Eng.

eISSN

1745-6215

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

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