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Accessing highly-halogenated flavanones using protic ionic liquids and microwave irradiation

journal contribution
posted on 2012-01-01, 00:00 authored by Megan Thornton, Luke HendersonLuke Henderson, Nolene ByrneNolene Byrne, Fred PfefferFred Pfeffer
A series of highly-functionalized 2'-hydroxychalcones have been synthesized using a microwave-assisted Claisen-Schmidt condensation. Conversion of these 2'-hydroxychalcones to their corresponding flavanones was then performed utilizing protic ionic liquids (pIL) and microwave irradiation. This methodology drastically reduces reaction time to 15 minutes compared to typical thermal methods (24 hrs) and is tolerant to a broad range of functional groups. Several chalcones reported bear four and five substituents - a degree of substitution rarely reported in the literature.

History

Journal

Current organic chemistry

Volume

16

Issue

1

Pagination

121 - 126

Publisher

Bentham Science Publishers Ltd

Location

Bussum, Netherlands

ISSN

1385-2728

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2012, Bentham Science Publishers