Deakin University
Browse

File(s) not publicly available

Alcohol-related diols cause acute insulin resistance in vivo

journal contribution
posted on 1998-01-01, 00:00 authored by D Xu, Amardeep DhillonAmardeep Dhillon, A Abelmann, K Croft, T J Peters, T N Palmer
Epidemiological studies suggest that alcohol consumption is an independent risk factor for the development of non-insulin-dependent diabetes mellitus (NIDDM). Alcoholism is known to be associated with increased plasma levels of two novel diols, 2,3-butanediol and 1,2-propanediol, metabolites known to impair insulin action in isolated adipocytes. This study examines whether 2,3-butanediol and 1,2-propanediol have the capacity to impair insulin action acutely in vivo in the rat. Using the euglycemic- hyperinsulinemic clamp, it is shown that the two diols reduce whole-body glucose utilization (by ~30%), with the onset of insulin resistance in vivo occurring at plasma concentrations of 2,3-butanediol (33 μmol/L) at least one order of magnitude (P < .001) lower than 1,2-propanediol (432 μmol/L). Tracer methodologies using [U-14C]glucose and 2-deoxy[13H]glucose indicate that the reduction in whole-body glucose utilization is accompanied by a reduction in glucose uptake and glycogen synthesis in the skeletal muscle and heart. The association between elevated plasma diol levels and insulin resistance demonstrated in this report raises the question of whether there is a link between the high plasma diol levels in alcohol abusers and their increased susceptibility to NIDDM.

History

Journal

Metabolism: Clinical and Experimental

Volume

47

Issue

10

Pagination

1180 - 1186

ISSN

0026-0495

Publication classification

C1.1 Refereed article in a scholarly journal

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC