scott-associationsofhealthrelated-2019.pdf (503.21 kB)
Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass
journal contribution
posted on 2019-09-01, 00:00 authored by Anoohya Gandham, Lachlan B McMillan, Carrie-Anne Ng, Ludovic Humbert, Maxine P Bonham, Ayse Zengin, Peter R Ebeling, David ScottDavid ScottHealth-related quality of life (HRQoL) and physical function deteriorate with age and may adversely impact bone health in older adults. We determined associations of objective measures of physical function and HRQoL with bone health in postmenopausal women with low areal bone mineral density (aBMD). Fifty postmenopausal women (64.4 7.7 years old, mean standard deviation) with low spine, hip or femoral neck aBMD (T- or Z-score < −1.0) on dual-energy X-ray absorptiometry (DXA) participated. Femoral surface BMD, trabecular, integral and cortical volumetric BMD (vBMD) measurements were obtained using 3D-SHAPER software on DXA. Distal tibial vBMD and microarchitecture were assessed using high-resolution peripheral quantitative computed tomography (HRpQCT). Participants completed self-administered EuroQol-5D (EQ-5D) and modified falls efficacy scale (MFES) questionnaires, and physical function assessments. Stair climb power was positively associated with bone parameters at the hip, femoral neck, and distal tibia (all p < 0.05) in multivariable linear regression. EQ-5D demonstrated no significant associations with bone parameters and MFES was positively associated only with distal tibial cortical vBMD and cortical von Mises stress (both p < 0.05). Objective measures of physical function, particularly muscle power, are more consistently associated with bone parameters compared with self-administered HRQoL questionnaires.
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Journal
Journal of clinical medicineVolume
8Issue
9Article number
1370Pagination
1 - 13Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
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ISSN
2077-0383eISSN
2077-0383Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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