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Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution
journal contribution
posted on 2022-05-09, 00:00 authored by Antoine DujonAntoine Dujon, J Boutry, S Tissot, J F Lemaître, A M Boddy, A L Gérard, A Alvergne, A Arnal, O Vincze, D Nicolas, M Giraudeau, Marina Telonis-ScottMarina Telonis-Scott, Aaron SchultzAaron Schultz, P Pujol, Peter BiroPeter Biro, Christa BeckmannChrista Beckmann, R Hamede, B Roche, Beata UjvariBeata Ujvari, F ThomasReproduction is one of the most energetically demanding life-history stages. As a result, breeding individuals often experience trade-offs, where energy is diverted away from maintenance (cell repair, immune function) toward reproduction. While it is increasingly acknowledged that oncogenic processes are omnipresent, evolving and opportunistic entities in the bodies of metazoans, the associations among reproductive activities, energy expenditure, and the dynamics of malignant cells have rarely been studied. Here, we review the diverse ways in which age-specific reproductive performance (e.g., reproductive aging patterns) and cancer risks throughout the life course may be linked via trade-offs or other mechanisms, as well as discuss situations where trade-offs may not exist. We argue that the interactions between host–oncogenic processes should play a significant role in life-history theory, and suggest some avenues for future research.
History
Journal
Frontiers in Ecology and EvolutionVolume
10Publisher DOI
eISSN
2296-701XPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Keywords
Science & TechnologyLife Sciences & BiomedicineEcologyEnvironmental Sciences & Ecologydiseasesexual selectionreproductionreproductive agingneoplasiatransmissible cancersenescenceBREAST-CANCERTRADE-OFFSPROSTATE-CANCEROXIDATIVE STRESSIMMUNE-RESPONSECLIMATE-CHANGEMISSING LINKDNA-DAMAGEAGEEvolutionary BiologyEcology
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