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Cancer stem cells: a contentious hypothesis now moving forward
journal contribution
posted on 2014-03-28, 00:00 authored by M L O'Connor, Dongxi Xiang, Sarah ShigdarSarah Shigdar, Joanna MacdonaldJoanna Macdonald, Y Li, Tao Wang, C Pu, Z Wang, L Qiao, Wei DuanWei DuanCancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.
History
Journal
Cancer lettersVolume
344Issue
2Pagination
180 - 187Publisher
Elsevier IrelandLocation
Shannon, IrelandPublisher DOI
eISSN
1872-7980Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2014, Elsevier IrelandUsage metrics
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No categories selectedKeywords
AptamersCancer stem cellsChemoresistanceClonal evolutionStemnessAnimalsDrug Resistance, NeoplasmHumansNeoplasmsNeoplastic Stem CellsScience & TechnologyLife Sciences & BiomedicineOncologyBREAST-CANCERTUMOR-GROWTHPROSPECTIVE IDENTIFICATIONDRUG-RESISTANCESOLID TUMORSPOPULATIONNOTCHLEUKEMIATHERAPYAnimals Drug Resistance, Neoplasm Humans Neoplasms\/drug therapy\/*pathology Neoplastic Stem Cells\/*pathology Aptamers Cancer stem cells Chemoresistance Clonal evolution Stemness
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