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Cancer stem cells: a contentious hypothesis now moving forward

journal contribution
posted on 2014-03-28, 00:00 authored by M L O'Connor, Dongxi Xiang, Sarah ShigdarSarah Shigdar, Joanna MacdonaldJoanna Macdonald, Y Li, Tao Wang, C Pu, Z Wang, L Qiao, Wei DuanWei Duan
Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.

History

Journal

Cancer letters

Volume

344

Issue

2

Pagination

180 - 187

Publisher

Elsevier Ireland

Location

Shannon, Ireland

eISSN

1872-7980

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2014, Elsevier Ireland