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Chemical and physical processes for integrated temperature control in microfluidic devices
journal contribution
posted on 2003-01-01, 00:00 authored by Rosanne GuijtRosanne Guijt, A Dodge, G W K van Dedem, N F de Rooij, E VerpoorteMicrofluidic devices are a promising new tool for studying and optimizing (bio)chemical reactions and analyses. Many (bio)chemical reactions require accurate temperature control, such as for example thermocycling for PCR. Here, a new integrated temperature control system for microfluidic devices is presented, using chemical and physical processes to locally regulate temperature. In demonstration experiments, the evaporation of acetone was used as an endothermic process to cool a microchannel. Additionally, heating of a microchannel was achieved by dissolution of concentrated sulfuric acid in water as an exothermic process. Localization of the contact area of two flows in a microfluidic channel allows control of the position and the magnitude of the thermal effect.
History
Journal
Lab on a chipVolume
3Issue
1Pagination
1 - 4Publisher
Royal Society of ChemistryLocation
Cambridge, Eng.Publisher DOI
ISSN
1473-0197eISSN
1473-0189Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2003, Royal Society of ChemistryUsage metrics
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No categories selectedKeywords
Equipment DesignMicrochemistryMicrofluidicsOligonucleotidesTemperatureScience & TechnologyLife Sciences & BiomedicinePhysical SciencesTechnologyBiochemical Research MethodsChemistry, MultidisciplinaryChemistry, AnalyticalNanoscience & NanotechnologyInstruments & InstrumentationBiochemistry & Molecular BiologyChemistryScience & Technology - Other TopicsMOLECULAR BEACONSAMPLIFICATIONSYSTEMPCR
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