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Chronic traumatic encephalopathy: historical origins and current perspective.
journal contribution
posted on 2015-03-01, 00:00 authored by P H Montenigro, Daniel CorpDaniel Corp, T D Stein, R C Cantu, R A SternChronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is most often identified in postmortem autopsies of individuals exposed to repetitive head impacts, such as boxers and football players. The neuropathology of CTE is characterized by the accumulation of hyperphosphorylated tau protein in a pattern that is unique from that of other neurodegenerative diseases, including Alzheimer's disease. The clinical features of CTE are often progressive, leading to dramatic changes in mood, behavior, and cognition, frequently resulting in debilitating dementia. In some cases, motor features, including parkinsonism, can also be present. In this review, the historical origins of CTE are revealed and an overview of the current state of knowledge of CTE is provided, including the neuropathology, clinical features, proposed clinical and pathological diagnostic criteria, potential in vivo biomarkers, known risk factors, and treatment options.
History
Journal
Annual review of clinical psychologyVolume
11Pagination
309 - 330Publisher
Annual ReviewsLocation
Palo Alto, Calif.eISSN
1548-5951Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, Annual ReviewsUsage metrics
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chronic traumatic encephalopathyconcussionfootballhistoryneurodegenerative disorderstraumatic brain injuryBiomarkersBoxingBrainBrain Injury, ChronicHistory, 20th CenturyHistory, 21st CenturyHumansNeuroimagingRisk FactorsSocial SciencesPsychology, ClinicalPsychologyAPOLIPOPROTEIN-E-GENOTYPEREPETITIVE BRAIN TRAUMALONG-TERM CONSEQUENCESWHITE-MATTER INTEGRITYMILD HEAD-INJURYHIGH-SCHOOLALZHEIMERS-DISEASENEUROFIBRILLARY TANGLESRECURRENT CONCUSSIONFOOTBALL PLAYERS
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