ajji-combinationofbalsamin-2020.pdf (2.19 MB)
Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells
Flavonoids such as naringenin, quercetin, and naringin are known to exhibit anticancer properties. In this study, we examined the effects of these flavonoids on cell viability and apoptotic pathways of cancer cells, either singly or in combination with the type 1 ribosome inactivating protein, Balsamin. Treatment with flavonoids (naringenin, quercetin, and naringin) plus Balsamin for 48 h reduced HepG2 and MCF-7 cell viability, increased the activation of caspase-3 and -8, and induced apoptosis through up-regulation of pro-apoptotic genes and down-regulation of anti-apoptotic genes. Out of the three flavonoids tested, the Balsamin-Naringenin and Balsamin-Quercetin combinations appeared to be most effective compared to the Balsamin-Naringin combination. Balsamin combined with flavonoids also activated endoplasmic reticulum (ER)-stress–mediated apoptosis in breast cancer (MCF-7) cells, which was not activated by Balsamin treatment alone. These experimental results showed that Balsamin combined with flavonoids can reduce HepG2 and MCF-7 cells viability and induce apoptosis, which could be considered as a promising therapeutic approach to sensitize cells to Balsamin treatment, thereby improving its efficacy in breast or liver cancer therapy.
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Journal
Frontiers in PharmacologyVolume
11Article number
574496Pagination
1 - 13Publisher
Frontiers MediaLocation
Lausanne, SwitzerlandPublisher DOI
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ISSN
1663-9812eISSN
1663-9812Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2020, Ajji, Walder and PuriUsage metrics
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