dodd-combinationpharmacotherapy.pdf (1.39 MB)
Combination pharmacotherapy in unipolar depression
journal contribution
posted on 2006-07-01, 00:00 authored by F Ng, Seetal DoddSeetal Dodd, Michael BerkMichael BerkIt is estimated that between 60 and 80% of those with major depressive disorder do not achieve full symptomatic remission from first-line antidepressant monotherapy. Residual depressive symptoms substantially impair quality of life and add to the risk of recurrence. It is now clear that depression would benefit from more vigorous treatment, in order to ameliorate its disease burden. While there are established algorithms in situations of treatment resistance, the use of combination pharmacotherapy in unipolar depression is a relatively under-investigated area of treatment and may be an effective and tolerable strategy that maximizes the available resources. This paper reviews the current evidence for combination pharmacotherapy in unipolar depression and discusses its clinical applications.
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Journal
Expert review of neurotherapeuticsVolume
6Issue
7Pagination
1049 - 1060Publisher
Expert ReviewsLocation
London, EnglandPublisher DOI
ISSN
1473-7175eISSN
1744-8360Language
engNotes
Reproduced with the kind permission of the copyright owner.Publication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2006, Expert ReviewsUsage metrics
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