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Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases : a pooled analysis of primary data from three studies across international settings
journal contribution
posted on 2015-01-01, 00:00 authored by J Knox, M Van Rijen, A C Uhlemann, M Miller, C Hafer, P Vavagiakis, Q Shi, P D Johnson, G Coombs, M Kluytmans-Van Den Bergh, J Kluytmans, Catherine BennettCatherine Bennett, F D LowyDiverse strain types of methicillin-resistant Staphylococcus aureus (MRSA) cause infections in community settings worldwide. To examine heterogeneity of spread within households and to identify common risk factors for household transmission across settings, primary data from studies conducted in New York (USA), Breda (The Netherlands), and Melbourne (Australia) were pooled. Following MRSA infection of the index patient, household members completed questionnaires and provided nasal swabs. Swabs positive for S. aureus were genotyped by spa sequencing. Poisson regression with robust error variance was used to estimate prevalence odds ratios for transmission of the clinical isolate to non-index household members. Great diversity of strain types existed across studies. Despite differences between studies, the index patient being colonized with the clinical isolate at the home visit (P < 0·01) and the percent of household members aged <18 years (P < 0·01) were independently associated with transmission. Targeted decolonization strategies could be used across geographical settings to limit household MRSA transmission.
History
Journal
Epidemiology and InfectionVolume
143Issue
2Pagination
354 - 365Publisher
Cambridge University PressLocation
Cambridge, United KingdomPublisher DOI
eISSN
1469-4409Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, Cambridge University PressUsage metrics
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No categories selectedKeywords
AdolescentAdultAustraliaChildChild, PreschoolCommunity-Acquired InfectionsFamily CharacteristicsFemaleHumansInfantMaleMethicillin-Resistant Staphylococcus aureusNetherlandsNew YorkRetrospective StudiesStaphylococcal InfectionsYoung AdultInfectious disease epidemiologymethicillin-resistant S. aureus (MRSA)Staphylococcus aureustransmissionScience & TechnologyLife Sciences & BiomedicinePublic, Environmental & Occupational HealthInfectious DiseasesFAMILIAL TRANSMISSIONNASAL COLONIZATIONRISK-FACTORSCONTACTSEPIDEMIOLOGYCARRIAGEMRSAPREVALENCECHILDRENDURATION
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