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Coprocytobiology: A Technical Review of Cytological Colorectal Cancer Screening in Fecal Samples
journal contribution
posted on 2021-01-01, 00:00 authored by L Ryan, Yen Ting WongYen Ting Wong, Karen DwyerKaren Dwyer, D Clarke, L Kyprian, Jeffrey CraigJeffrey CraigThis review discusses the field of coprocytobiology, defined as a combined method of cell preservation, isolation, and cytology, which has applications to the investigation of noninvasive fecal screening for colorectal cancer. In the decade since the field was last reviewed, cell isolation has progressed rapidly via the development of technologies such as microfluidic and magnetic cell sorting. The landscape of cytology has also advanced in this time with the emergence of novel cytological methods and cell preservation strategies. Previous reviews present an outdated and incomplete view of coprocytobiology, summarizing a limited number of early publications, ignoring the principle of cell preservation and focusing on a single method of isolation rather than the field as a whole. In contrast to these publications, this review presents an updated, comprehensive, and unbiased representation of the technical aspects of coprocytobiology and provides unique insight into the common methodological pitfalls, best practice, and future directions of cytological screening for colorectal cancer. Graphical Abstract
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Journal
SLAS Technology : translating life sciences innovationArticle number
24726303211024562Pagination
1 - 14Publisher
SageLocation
London, Eng.Publisher DOI
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2472-6303eISSN
2472-6311Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
Biochemical Research MethodsBiochemistry & Molecular Biologycell isolationChemistryChemistry, AnalyticalCOLONIC EPITHELIAL-CELLScolorectal cancercoprocytobiologyCOST-EFFECTIVENESScytologyDNAEXFOLIATED COLONOCYTESEXPRESSIONfecesHUMAN STOOLLife Sciences & BiomedicineNONINVASIVE DETECTIONPhysical SciencesRELEVANCEScience & TechnologySURFACE
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