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Current designs of polymer blends in solid dispersions for improving drug bioavailability
journal contribution
posted on 2018-01-01, 00:00 authored by Phuong TranPhuong Tran, Wei DuanWei Duan, Beom-Jin Lee, Thao Td TranTernary solid dispersions have been demonstrated to be an effective strategy in the improvement of drug absorption and bioavailability. The applications of the combination of hydrophilic polymers with the potential of hydrophobic polymer incorporation at moderate concentrations have been discussed in recent publications. In this paper, the general review of this specific type of solid dispersion will be provided with comprehensive understanding of polymer blends of either hydrophilic or hydrophobic polymers. A detailed description of miscible polymers has been developed in recent studies. In addition to dissolution rate improvement, the role of second polymers in crystal growth inhibition and in maintaining the amorphous state will be mentioned. We also present a summary of characterization techniques commonly used to evaluate solid dispersion and polymer miscibility.
History
Journal
Current drug metabolismVolume
19Issue
13Pagination
1111 - 1118Publisher
Bentham Science PublishersLocation
Beijing, ChinaPublisher DOI
eISSN
1875-5453Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2018, Bentham Science PublishersUsage metrics
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No categories selectedKeywords
ternary solid dispersionhydrophilic-hydrophobic polymerpolymer miscibilitypoorly water-soluble drugs.Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyPharmacology & Pharmacypoorly water-soluble drugspolymer blenddissolutionWATER-SOLUBLE DRUGIN-VITRO DISSOLUTIONARTIFICIAL NEURAL-NETWORKSHPMC MOLECULAR-WEIGHTMELT MIXING TECHNIQUESPRAY-DRYING PROCESSPHYSICOCHEMICAL CHARACTERIZATIONORAL BIOAVAILABILITYCONTROLLED-RELEASEPVP K30
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