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Current perspectives on delivery systems using extracellular vesicles in neurological disease
journal contribution
posted on 2020-01-01, 00:00 authored by Phuong TranPhuong Tran, Wei DuanWei Duan, B J Lee, T T D TranExtracellular vesicles have an excellent ability to transfer their contents to cells. Extracellular vesicles can also be engineered to deliver therapeutic molecules to target cells. Although a number of studies have exploited synthesized nanoparticles in the treatment of neurological disease in the past few years, extracellular vesicles have been investigated and shown tremendous promise for clinical applications because they are safe and have strong targeting specificity. Different types of extracellular vesicles have been studied and modified for delivering therapeutic factors in neurological disease, including extracellular vesicles loaded with natural therapeutic factors and therapeutic molecules. In this review, we discuss delivery systems using extracellular vesicles containing molecules of interest and then focus on main strategies used for EV loading and surface modification. Discussing these important issues will support and facilitate the design and development of promising techniques and products for neurological therapy.
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Journal
Current pharmaceutical designVolume
26Issue
7Pagination
764 - 771Publisher
Bentham ScienceLocation
Sharjah, United Arab EmiratesPublisher DOI
ISSN
1381-6128eISSN
1873-4286Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyExtracellular vesiclesneurological diseasetherapeutic moleculesloadingdelivery systemspecificityMESENCHYMAL STROMAL CELLSEXOSOME-MEDIATED DELIVERYSTEM-CELLSIN-VITROSTEM\/PROGENITOR CELLSPARKINSONS-DISEASECEREBRAL-ISCHEMIAMEMBRANE-VESICLESSERUM EXOSOMESAMYLOID-BETAtherapeutic molecules.
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