kim-dopamaphigh-2022.pdf (6.29 MB)
DOPAMAP, high-resolution images of dopamine 1 and 2 receptor expression in developing and adult mouse brains
journal contribution
posted on 2022-01-01, 00:00 authored by I E Bjerke, E R Cullity, K Kjelsberg, K M Charan, T B Leergaard, Jee Hyun KimJee Hyun KimAbstractThe dopaminergic system undergoes major reorganization during development, a period especially vulnerable to mental disorders. Forebrain neurons expressing dopamine 1 and 2 receptors (D1R and D2R, respectively) play a key role in this system. However, neuroanatomical information about the typical development of these neurons is sparse and scattered across publications investigating one or a few brain regions. We here present a public online collection of microscopic images of immunohistochemically stained serial sections from male and female mice at five stages of development (postnatal day 17 (P17), P25, P35, P49, and adult), showing the distribution of D1R and D2R expressing neurons across the forebrain. All images from adult brains are registered to the Allen Mouse brain Common Coordinate Framework, while images from P17-P35 age groups are registered to spatially modified atlas versions matching the morphology of young brains. This online resource provides microscopic visualization of the developing dopaminergic system in mice, which is suitable as a benchmark reference for performing new experiments and building computational models of the brain.
History
Journal
Scientific DataVolume
9Issue
1Article number
ARTN 175Pagination
1 - 11Publisher
Springer NatureLocation
Berlin, NetherlandsPublisher DOI
Link to full text
ISSN
2052-4463eISSN
2052-4463Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC