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Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines
journal contribution
posted on 2008-02-11, 00:00 authored by I G Macreadie, T D Avery, T V Robinson, Peter MacreadiePeter Macreadie, M Barraclough, D K Taylor, E R T TiekinkIn an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure-activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were assessed primarily against the pathogenic yeast, Candida albicans, with haemolytic activity of selected examples also reported. © 2007 Elsevier Ltd. All rights reserved.