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Design of fucoidan functionalized - iron oxide nanoparticles for biomedical applications
journal contribution
posted on 2016-01-01, 00:00 authored by H Tran, Phuong Tran, T Vo, T TranThis research aims to develop an iron oxide nanoparticle drug delivery system utilizing a recent material discovered from ocean, fucoidan. The material has drawn much interest due to many biomedical functions that have been proven for human health. One interesting point herein is that fucoidan is not only a sulfated polysaccharide, a polymer for stabilization of iron oxide nanoparticles, but plays a role of an anticancer agent also. Various approaches were investigated to optimize the high loading efficiency and explain the mechanism of nanoparticle formations. Fucoidan was functionalized on iron oxide nanoparticles by a direct coating or via amine groups. Also, a hydrophobic part of oleic acid was conjugated to the amine groups for a more favorable loading of poorly water-soluble anticancer drugs. This study proposed a novel system and an efficient method to functionalize fucoidan on iron oxide nanoparticle systems which will lead to a facilitation of a double strength treatment of cancer.
History
Journal
Current drug deliveryVolume
13Issue
5Pagination
774 - 783Publisher
Bentham ScienceLocation
Beijing, ChinaPublisher DOI
ISSN
1567-2018Language
engPublication classification
C1 Refereed article in a scholarly journal; C Journal articleCopyright notice
2016, Bentham ScienceUsage metrics
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