barry-designingmalaria-2015.pdf (1.1 MB)
Designing malaria vaccines to circumvent antigen variability
journal contribution
posted on 2015-12-22, 00:00 authored by A Ouattara, Alyssa BarryAlyssa Barry, S Dutta, E J Remarque, J G Beeson, C V Plowe© 2015. Prospects for malaria eradication will be greatly enhanced by an effective vaccine, but parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent pre-clinical and field trials, vaccines based on polymorphic Plasmodium falciparum antigens have shown efficacy only against homologous strains, raising the specter of allele-specific immunity such as that which plagues vaccines against influenza and HIV. The most advanced malaria vaccine, RTS, S, targets relatively conserved epitopes on the P. falciparum circumsporozoite protein. After more than 40 years of development and testing, RTS, S, has shown significant but modest efficacy against clinical malaria in phase 2 and 3 trials. Ongoing phase 2 studies of an irradiated sporozoite vaccine will ascertain whether the full protection against homologous experimental malaria challenge conferred by high doses of a whole organism vaccine can provide protection against diverse strains in the field. Here we review and evaluate approaches being taken to design broadly cross-protective malaria vaccines.
History
Journal
VaccineVolume
33Issue
52Pagination
7506 - 7512Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
Link to full text
ISSN
0264-410XeISSN
1873-2518Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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MalariaVaccineDiversityHeterologousAllele-specific efficacyCross-protectionScience & TechnologyLife Sciences & BiomedicineImmunologyMedicine, Research & ExperimentalResearch & Experimental MedicineAPICAL MEMBRANE ANTIGEN-1PLASMODIUM-FALCIPARUM MALARIAGENETIC DIVERSITYPREERYTHROCYTIC STAGESPOPULATION-STRUCTUREREVERSE VACCINOLOGYSPOROZOITE VACCINEHUMAN IMMUNITYIMMUNIZATION
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