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Development of a modified - solid dispersion in an uncommon approach of melting method facilitating properties of a swellable polymer to enhance drug dissolution
journal contribution
posted on 2015-04-30, 00:00 authored by Tuong Ngoc Gia Nguyen, Phuong TranPhuong Tran, T V Tran, T V Vo, T Truong-DinhTranThe study aimed to develop a modified-solid dispersion method using a swellable hydrophilic polymers accompanied by a conventional carrier to enhance the dissolution of a drug that possesses poor water solubility. Two swellable polymers (hydroxypropyl methylcellulose and polyethylene oxide) were swelled in melted polyethylene glycol 6000 (PEG 6000) in different ratios and under different conditions. The type, amount, and, especially, incorporation method of the swellable polymers were crucial factors affecting the dissolution rate, crystallinity, and molecular interaction of the drug. Interestingly, the method in which the swellable polymer was thoroughly mixed with the melted PEG 6000 as the first step was more effective in increasing drug dissolution than the method in which the drug was introduced to the melted PEG 6000 followed by the addition of the swellable polymer. This system has potential for controlling drug release due to high swelling capabilities of these polymers. Therefore, the current study can be considered to be a promising model for formulations of controlled release systems containing solid dispersions.
History
Journal
International journal of pharmaceuticsVolume
484Issue
1-2Pagination
228 - 234Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
1873-3476Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2015, ElsevierUsage metrics
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No categories selectedKeywords
Controlled releaseMelting methodPoorly water-soluble drugSolid dispersionSwellable polymerChemistry, PharmaceuticalDrug DiscoveryDrug LiberationPolymersSolubilityScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyCURCUMINIMPROVEBIOAVAILABILITYCRYSTALLINITYABSORPTIONDELIVERYMIXTURE
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