mandarano-developmentof-2018.pdf (3.66 MB)
Development of transferrin receptor aptamers as drug delivery vehicles for the treatment of brain metastases
journal contribution
posted on 2018-01-01, 00:00 authored by Joanna Macdonald, Giovanni MandaranoGiovanni Mandarano, Rakesh Naduvile Veedu, Sarah ShigdarSarah ShigdarAffecting approximately up to 10-40% of all cancer patients, the prognosis for patients suffering from metastatic brain tumours is poor. Treatment of these metastatic tumours is greatly hindered by the presence of the blood brain barrier which restricts the overwhelming majority of small molecules from entering the brain. A novel approach to overcome this barrier is to target receptor mediated transport mechanisms present on the endothelial cell membranes, in particular the transferrin receptor. Given their specificity, safety profile and stability, nucleic acid-based therapeutics are ideal for this purpose. This review explores the development of bifunctional aptamers for the treatment of brain metastases.
History
Journal
AptamersVolume
2Pagination
15 - 27Publisher
International Society on AptamersLocation
Oxford, Eng.Link to full text
ISSN
2514-3247Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, The AuthorsUsage metrics
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