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Diffusion tensor imaging reveals no white matter impairments among adults with autism spectrum disorder
journal contribution
posted on 2015-07-30, 00:00 authored by Melissa KirkovskiMelissa Kirkovski, Peter EnticottPeter Enticott, J J Maller, S L Rossell, P B FitzgeraldAbnormalities within white matter (WM) have been identified in autism spectrum disorder (ASD). Although there is some support for greater neurobiological deficits among females with ASD, there is little research investigating sex differences in WM in ASD. We used diffusion tensor imaging (DTI) to investigate WM aberration in 25 adults with high-functioning ASD and 24 age-, sex- and IQ-matched controls. Tract-based spatial statistics (TBSS) was used to explore differences in WM in major tract bundles. The effects of biological sex were also investigated. TBSS revealed no differences in fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), or axial diffusivity (AD) between groups. There were no effects of biological sex. We consider whether methodological differences between past studies have contributed to the highly heterogeneous findings in the literature. Finally, we suggest that, among a high-functioning sample of adults with ASD, differences in WM microstructure may not be related to clinical impairment.
History
Journal
Psychiatry research - neuroimagingVolume
233Issue
1Pagination
64 - 72Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0925-4927eISSN
1872-7506Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2015, ElsevierUsage metrics
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No categories selectedKeywords
Autism spectrum disorderDiffusion tensor imagingGenderMagnetic resonance imagingTract-based spatial statisticsScience & TechnologyLife Sciences & BiomedicineClinical NeurologyNeuroimagingPsychiatryNeurosciences & NeurologyHIGH-FUNCTIONING AUTISMSPATIAL STATISTICSASPERGER SYNDROMECORPUS-CALLOSUMYOUNG-CHILDRENBRAIN VOLUMEINTEGRITYAGEMRIMICROSTRUCTURE
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