mundell-doesandrogendeprivation-2021.pdf (886.47 kB)
Does androgen deprivation impact associations between cognition and strength, fitness and function in community-dwelling men with prostate cancer? A cross-sectional study
journal contribution
posted on 2021-12-30, 00:00 authored by Niamh MundellNiamh Mundell, Patrick Owen, J Dalla Via, Helen MacphersonHelen Macpherson, Robin DalyRobin Daly, Steve FraserSteve FraserObjectives We investigated whether there were differences in associations between cognition with muscle strength, fitness and function in men with prostate cancer (PCa) treated with, and without androgen deprivation therapy (ADT) and non-PCa controls. A secondary aim
was to compare differences in the prevalence of cognitive impairment.
Design This cross-sectional study compared 70 ADT- treated men with PCa aged 50–85 years to non-ADT- treated men (n=52) and non-PCa controls (n=70).
Setting University clinical exercise laboratory. Interventions Nil.
Primary and secondary outcome
measures Standardised assessments were conducted for cognition (learning, memory, attention, processing speed and executive function), muscle strength (grip strength and leg press), fitness (400 m walk), gait speed (4 m walk) and dual-tasking mobility (timed-up-and-go with a cognitive
task).
Results ADT-treated men showed stronger associations between fitness and executive function and task switching relative to controls (both: p≤0.03). For both PCa groups (independent of ADT use), poorer dual-task mobility was more strongly associated with decreased psychomotor attention (both: p≤0.027) and global cognitive function (both: p≤0.031) compared with non-PCa controls. The overall prevalence of cognitive impairment was low (4%– 13%) and did not differ between the groups.
Conclusions ThepresenceofPCa,withorwithoutADT treatment, did not increase the risk of cognitive impairment relative to non-PCa controls, yet did alter the associations between physical fitness and some measures of functional performance with certain cognitive domains. This highlights the importance of men with PCa maintaining fitness and functional capacity to optimise cognitive health.
Trial registration number This study was registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12614000317695).
was to compare differences in the prevalence of cognitive impairment.
Design This cross-sectional study compared 70 ADT- treated men with PCa aged 50–85 years to non-ADT- treated men (n=52) and non-PCa controls (n=70).
Setting University clinical exercise laboratory. Interventions Nil.
Primary and secondary outcome
measures Standardised assessments were conducted for cognition (learning, memory, attention, processing speed and executive function), muscle strength (grip strength and leg press), fitness (400 m walk), gait speed (4 m walk) and dual-tasking mobility (timed-up-and-go with a cognitive
task).
Results ADT-treated men showed stronger associations between fitness and executive function and task switching relative to controls (both: p≤0.03). For both PCa groups (independent of ADT use), poorer dual-task mobility was more strongly associated with decreased psychomotor attention (both: p≤0.027) and global cognitive function (both: p≤0.031) compared with non-PCa controls. The overall prevalence of cognitive impairment was low (4%– 13%) and did not differ between the groups.
Conclusions ThepresenceofPCa,withorwithoutADT treatment, did not increase the risk of cognitive impairment relative to non-PCa controls, yet did alter the associations between physical fitness and some measures of functional performance with certain cognitive domains. This highlights the importance of men with PCa maintaining fitness and functional capacity to optimise cognitive health.
Trial registration number This study was registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12614000317695).
History
Journal
BMJ OpenVolume
11Issue
12Article number
e058478Pagination
1 - 12Publisher
BMJ Publishing GroupLocation
London, EnglandPublisher DOI
Link to full text
ISSN
2044-6055eISSN
2044-6055Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC