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Drug stabilization in the gastrointestinal tract and potential applications in the colonic delivery of oral zein-based formulations
journal contribution
posted on 2019-10-01, 00:00 authored by Phuong TranPhuong Tran, Wei DuanWei Duan, B J Lee, T T D TranIn recent years, various oral dosage forms using biomaterials have been developed to deliver drugs to the colon for therapy due to the advantages of local treatment and its ideal location for drug delivery. To achieve site-specific delivery, the complete drug should be released in the colon, while the drug must be protected or their delivery minimized in the stomach and small intestine. The use of natural or synthetic polymers has been reported for these purposes. The roles of zein in drug delivery have been identified with various types of formulations for improving bioavailability, controlled drug release and targeted delivery. Although zein has been demonstrated as a potential material for pharmaceutical applications, a review of zein in the gastrointestinal tract for stabilizing drug- and colon-specific delivery is still missing. In the present review, we aim to provide typical strategies for using zein in formulations to minimize drug release/ensure drug protection in the upper part of the gastrointestinal tract. Furthermore, effective fabrications or modifications for drug release in the colon will be highlighted. This primary resource of related methods of using zein in the gastrointestinal tract will advance technologies for using it as a natural polymer for drug delivery.
History
Journal
International journal of pharmaceuticsVolume
569Article number
118614Pagination
1 - 6Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0378-5173eISSN
1873-3476Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, ElsevierUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyDrug stabilizationColon-specific deliveryZeinOral deliveryControlled drug releaseWATER-VAPOR PERMEABILITYIN-VIVO EVALUATIONBETA-CAROTENESOLID DISPERSIONSCOMPOSITE NANOPARTICLESCONTROLLED-RELEASEESSENTIAL OILSCORN PROTEINVITROSYSTEMS
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