pasco-dynapeniaandlow-2021.pdf (237.39 kB)
Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
journal contribution
posted on 2021-01-06, 00:00 authored by Julie PascoJulie Pasco, Amanda StuartAmanda Stuart, Sophia Sui, Kara KewKara Kew, Natalie HydeNatalie Hyde, Monica Chimwemwe Tembo, Pam Rufus-MemberePam Rufus-Membere, Mark KotowiczMark Kotowicz, Lana WilliamsLana WilliamsDynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Participants were 127 women aged 51–87 years, from the Geelong Osteoporosis Study. Peak eccentric strength of the hip-flexors and hip abductors was determined using a hand-held dynamometer, and dynapenia identified as muscle strength t-scores < −1. Cognition was assessed using the Mini-Mental State Examination (MMSE), and MMSE scores below the median were rated as low. Associations between dynapenia and low cognition were examined using logistic regression models. Hip-flexor dynapenia was detected in 38 (71.7%) women with low cognition and 36 (48.7%) with good cognition (p = 0.009); for hip abductor dynapenia, the pattern was similar (21 (39.6%) vs. 9 (12.2%); p < 0.001). While the observed difference for hip-flexor strength was attenuated after adjusting for age and height (adjusted Odds Ratio (OR) 1.95, 95%CI 0.86–4.41), low cognition was nearly 4-fold more likely in association with hip abductor dynapenia (adjusted OR 3.76, 95%CI 1.44–9.83). No other confounders were identified. Our data suggest that low strength of the hip abductors and low cognition are associated and this could be a consequence of poor muscle function contributing to cognitive decline or vice versa. As muscle weakness is responsive to physical interventions, this warrants further investigation.
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Journal
Journal of Clinical MedicineVolume
10Issue
2Article number
173Pagination
1 - 7Publisher
MDPI AGLocation
Basel, SwitzerlandPublisher DOI
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2077-0383eISSN
2077-0383Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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