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Effect of the initial dose of foot-and-mouth disease virus on the early viral dynamics within pigs
journal contribution
posted on 2009-10-06, 00:00 authored by R Howey, M Quan, N J Savill, L Matthews, Soren AlexandersenSoren Alexandersen, M WoolhouseThis paper investigates the early viral dynamics of foot-and-mouth disease (FMD) within infected pigs. Using an existing within-host model, we investigate whether individual variation can be explained by the effect of the initial dose of FMD virus. To do this, we consider the experimental data on the concentration of FMD virus genomes in the blood (viral load). In this experiment, 12 pigs were inoculated with one of three different doses of FMD virus: low; medium; or high. Measurements of the viral load were recorded over a time course of approximately 11 days for every 8 hours. The model is a set of deterministic differential equations with the following variables: viral load; virus in the interstitial space; and the proportion of epithelial cells available for infection, infected and uninfected. The model was fitted to the data for each animal individually and also simultaneously over all animals varying only the initial dose. We show that the general trend in the data can be explained by varying only the initial dose. The higher the initial dose the earlier the development of a detectable viral load.
History
Journal
Journal of the Royal Society. InterfaceVolume
6Issue
39Pagination
835 - 847Publisher
Royal Society PublishingLocation
London, Eng.Publisher DOI
ISSN
1742-5689eISSN
1742-5662Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2008, Royal SocietyUsage metrics
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No categories selectedKeywords
pigfoot-and-mouth diseasedosedifferential equation modelwithin-host modelAnimalsComputer SimulationFoot-and-Mouth Disease VirusModels, BiologicalSwineSwine DiseasesViral LoadScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsMODEL SELECTIONUNITED-KINGDOMSMALL SAMPLESPATHOGENESISINFECTIONTHERAPYDECAYTIMETRANSMISSIONCLEARANCE
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