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Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth
journal contribution
posted on 2011-01-01, 00:00 authored by X Huang, R Gong, Jia Lin, R Li, L Xiao, Wei DuanWei Duan, D FangA high-carbohydrate low-fat (HC/LF) diet and lipoprotein lipase gene (LPL) Ser447Stop and Hind III polymorphisms have separately been found to be associated with triacylglycerol (TG) and high density lipoprotein cholesterol (HDL-C). This study sought to test the effects of LPL polymorphisms and an HC/LF diet on the serum lipid profile of Chinese with a lower incidence of coronary artery disease (CAD) consuming a diet with less fat and more carbohydrates. Fifty-six healthy subjects (22.89 ± 1.80 years) were given a control diet of 30.1% fat and 54.1% carbohydrates for 7 days, followed by an HC/LF diet of 13.8% fat and 70.1% carbohydrate for 6 days; there were no changes in the fatty acid composition or restrictions on total energy. Serum lipid profiles at baseline, before and after the HC/LF diet, and LPL polymorphisms were analyzed. After 6 days of the HC/LF diet, TG and the homeostasis model assessment of insulin resistance (HOMAIR) index were found to increase only in females with S447S. No decrease in HDL-C was noted. In subjects with Hind III polymorphism, increased TG was found in all females but not in males. Increased HDL-C, together with apolipoprotein (apo) AI, was found in male H- carriers but not in males with H+/H+ and females. In conclusion, LPL Ser447Stop and Hind III polymorphisms modified the effects of an HC/LF diet on the serum lipid profiles of a young Chinese population in different ways. Effective strategies for dietary interventions targeted at younger populations should take into account the interplay between genetic polymorphisms, diet, and gender.
History
Journal
Bioscience trendsVolume
5Issue
5Pagination
198 - 204Publisher
International Advancement Centre for Medicine & Health Research Co., LtdLocation
Tokyo, JapanPublisher DOI
Link to full text
ISSN
1881-7815eISSN
1881-7823Language
engPublication classification
C1 Refereed article in a scholarly journal; C Journal articleUsage metrics
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high-carbohydrate low-fat dietlipoprotein lipaseSNPserum lipidsglucoseinsulin resistanceScience & TechnologyLife Sciences & BiomedicineBiologyLife Sciences & Biomedicine - Other TopicsCORONARY-ARTERY-DISEASEPLASMA-LIPIDSMYOCARDIAL-INFARCTIONINSULIN-RESISTANCEAPOPROTEIN-BHIGH-RISKPOLYMORPHISMPOPULATIONLPLMEN
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