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Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial

journal contribution
posted on 2019-05-01, 00:00 authored by Melanie AshtonMelanie Ashton, Michael BerkMichael Berk, Chee H Ng, Malcolm Hopwood, Seetal DoddSeetal Dodd, Alyna TurnerAlyna Turner, Eleanor Brown, Felice JackaFelice Jacka, Susan M Cotton, Jon-Paul Khoo, Mary Lou Chatterton, Bianca KavanaghBianca Kavanagh, Sarah E Nadjidai, Samantha L Lo Monaco, Brian H Harvey, Jerome Sarris, Gin S Malhi, Nathan L Dowling, Olivia DeanOlivia Dean
OBJECTIVE: Bipolar depression is characterized by neurobiological features including perturbed oxidative biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers. Bipolar depression manifests systemic inflammation, mitochondrial dysfunction, and changes in brain growth factors. The depressive phase of the disorder is the most common and responds the least to conventional treatments. Garcinia mangostana Linn, commonly known as mangosteen, is a tropical fruit. The pericarp's properties may reduce oxidative stress and inflammation and improve neurogenesis, making mangosteen pericarp a promising add-on therapy for bipolar depression. METHODS: Participants will receive 24 weeks of either 1,000 mg mangosteen pericarp or placebo per day, in addition to their usual treatment. The primary outcome is change in severity of mood symptoms, measured using the Montgomery-Åsberg Depression Rating Scale (MADRS), over the treatment phase. Secondary outcomes include global psychopathology, quality of life, functioning, substance use, cognition, safety, biological data, and cost-effectiveness. A follow-up interview will be conducted 4 weeks post-treatment. CONCLUSION: The findings of this study may have implications for improving treatment outcomes for those with bipolar disorder and may contribute to our understanding of the pathophysiology of bipolar depression. CLINICAL TRIAL REGISTRATION: Australian and New Zealand Clinical Trial Registry, ACTRN12616000028404.

History

Journal

Brazilian journal of psychiatry

Volume

41

Issue

3

Season

May/June

Pagination

245 - 253

Publisher

Brazilian Psychiatric Association

Location

Sao Paulo, Brazil

ISSN

1516-4446

eISSN

1809-452X

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

[2018, The Authors]

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