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Elevated hypothalamic beacon gene expression in Psammomys obesus prone to develop obesity and type 2 diabetes

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journal contribution
posted on 2002-05-01, 00:00 authored by Ken WalderKen Walder, E Ziv, R Kalman, K Whitecross, E Shafrir, P Zimmet, Gregory Collier
Objective: To investigate hypothalamic beacon gene expression at various developmental stages in genetically selected diabetes-resistant and diabetes-prone Psammomys obesus. In addition, effects of dietary energy composition on beacon gene expression were investigated in diabetes-prone P. obesus. Methods: Hypothalamic beacon gene expression was measured using TaqmanÔ fluorogenic PCR in 4-, 8- and 16-week-old animals from each genetically selected line. Results: Expression of beacon was elevated in the diabetes-prone compared with diabetes-resistant P. obesus at 4 weeks of age despite no difference in body weight between the groups. At 8 weeks of age, hypothalamic beacon gene expression was elevated in diabetes-prone animals fed a high-energy diet, and was correlated with serum insulin concentration. Conclusion: P. obesus with a genetic predisposition for the development of obesity and type 2 diabetes have elevated hypothalamic beacon gene expression at an early age. Overexpression of beacon may contribute to the development of obesity and insulin resistance in these animals.

History

Journal

International journal of obesity

Volume

26

Issue

5

Pagination

605 - 609

Publisher

Nature Publishing Group

Location

London, England

ISSN

0307-0565

eISSN

1476-5497

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2002, Nature Publishing Group