File(s) under permanent embargo
Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of AP0A5-1131T>C and AP0C3-482C> in chinese healthy young adults
journal contribution
posted on 2011-06-01, 00:00 authored by Jia Lin, D Fang, J Du, Sarah ShigdarSarah Shigdar, L Xiao, X Zhou, Wei DuanWei DuanBackground/aims: Changes in lipid profiles have been shown to be associated with diet and apolipoprotein (APO) polymorphisms. Therefore, 2 polymorphisms, i.e. APOA5-1131T>C and APOC3-482C>T, and serum lipids were examined in a Chinese healthy young population with high-carbohydrate/low-fat (HC/LF) diet intervention.
Methods: After a wash-out diet for 7 days, 56 young adults (22.89 +/- 1.80 years) received the HC/LF diet for 6 days. Body mass index (BMI) and fasting serum lipid profiles at baseline, after the wash-out diet, and after the HC/LF diet were measured.
Results: APOA5-1131C carriers had higher triglyceride (TG) and TG-rich lipoprotein TG (TRL-TG) levels at baseline and after the HC/LF diet, though this mainly corresponded to the female cohort. APOC3-482T carriers had higher TRL-TG levels following the wash-out and HC/LF diets, but these were not directly attributable to a single gender.
Conclusions: Both polymorphisms may play an important role in the elevated TG and TRL-TG levels induced by the HC/LF diet, especially in females, thus indicating a potential dietary prevention of coronary heart disease in this Chinese cohort.
Methods: After a wash-out diet for 7 days, 56 young adults (22.89 +/- 1.80 years) received the HC/LF diet for 6 days. Body mass index (BMI) and fasting serum lipid profiles at baseline, after the wash-out diet, and after the HC/LF diet were measured.
Results: APOA5-1131C carriers had higher triglyceride (TG) and TG-rich lipoprotein TG (TRL-TG) levels at baseline and after the HC/LF diet, though this mainly corresponded to the female cohort. APOC3-482T carriers had higher TRL-TG levels following the wash-out and HC/LF diets, but these were not directly attributable to a single gender.
Conclusions: Both polymorphisms may play an important role in the elevated TG and TRL-TG levels induced by the HC/LF diet, especially in females, thus indicating a potential dietary prevention of coronary heart disease in this Chinese cohort.
History
Journal
Annals of nutrition and metabolismVolume
58Issue
2Pagination
150 - 157Publisher
S. Karger AGLocation
Basel, SwitzerlandPublisher DOI
ISSN
0250-6807eISSN
1421-9697Language
engPublication classification
C1 Refereed article in a scholarly journal; C Journal articleCopyright notice
2011, S. Karger AGUsage metrics
Categories
No categories selectedKeywords
apolipoproteins A5 C3high-carbohydrate\/low-fat dietpolymorphismsserum lipidsScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismNutrition & DieteticsApolipoproteins A5, C3CORONARY-ARTERY-DISEASEAPOLIPOPROTEIN-A-VAMERICAN-HEART-ASSOCIATIONLOW-FAT DIETPLASMA-LIPIDSMETABOLIC SYNDROMECHOLESTEROL LEVELSETHNIC-GROUPSAPOA5 GENEHIGH-RISK
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC