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Enhanced solubility and modified release of poorly water-soluble drugs via self-assembled gelatin-oleic acid nanoparticles
journal contribution
posted on 2013-10-15, 00:00 authored by Phuong TranPhuong Tran, T T-D Tran, B-J LeeRecently, we synthesized novel amphiphilic gelatin-oleic acid (GO) conjugate to prepare self-assembled nanoparticles for drug delivery. The aim of this study was to investigate pharmaceutical potentialities of self-assembled GO nanoparticles for solubility enhancement and modified release of poorly water-soluble drugs. Three poorly water-soluble model drugs with different pH-dependent solubility (valsartan and aceclofenac, insoluble at pH 1.2; telmisartan, insoluble at pH 6.8) were chosen to investigate the potential contributions of self-assembled GO nanoparticles to solubility enhancement and controlled release. The particle size of the drug-loaded nanoparticles was 200-250 nm. Zeta potential was calculated, and instrumental analysis such as powder X-ray diffraction (PXRD) and Fourier transform infrared (FT-IR) spectroscopy were used to investigate the physicochemical properties of the drug-loaded nanoparticles. Compared to the drug alone, the drug-loaded nanoparticles showed enhanced solubility. Furthermore, the release profiles of the model drugs were modified in a controlled manner. The current self-assembled GO nanoparticles can provide a versatile potential in drug delivery and tumor targeting.
History
Journal
International journal of pharmaceuticsVolume
455Issue
1-2Pagination
235 - 240Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
1873-3476Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2013, ElsevierUsage metrics
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No categories selectedKeywords
Enhanced solubilityGelatin–oleic acid conjugateModified releasePoorly water-soluble drugsSelf-assembled nanoparticlespH-dependent solubilityBenzimidazolesBenzoatesDiclofenacGelatinNanoparticlesOleic AcidParticle SizePowder DiffractionSolubilitySpectroscopy, Fourier Transform InfraredTetrazolesValineValsartanWaterX-Ray DiffractionScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyGelatin-oleic acid conjugateDELIVERYGLYCOL
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