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Epigenetic discordance at imprinting control regions in twins
journal contribution
posted on 2011-06-01, 00:00 authored by Miina Ollikainen, Jeffrey CraigJeffrey CraigImprinting control regions are differentially methylated in a parent-of-origin-dependent manner and this methylation state is inherited through the germline. These regions control parent-specific monoallelic expression of their target genes. Genetically identical organisms show considerable variation in their epigenomes owing to environmental and stochastic influences creating fluctuations in phenotype. Monozygotic twin pairs discordant for imprinting disorders due to epigenetic changes at imprinting control regions are an example of phenotypic variation caused by extreme variations of the epigenome. Here, we discuss the within-pair epigenetic discordance at imprinted loci, both in phenotypically concordant and discordant monozygotic twin pairs.
History
Journal
EpigenomicsVolume
3Issue
3Pagination
295 - 306Publisher
Future MedicineLocation
London, Eng.Publisher DOI
eISSN
1750-192XLanguage
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2011, Future MedicineUsage metrics
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Keywords
DNA MethylationEpigenesis, GeneticGene-Environment InteractionGenomic ImprintingHumansModels, BiologicalPhenotypeStochastic ProcessesTwins, MonozygoticScience & TechnologyLife Sciences & BiomedicineGenetics & Heredityassisted reproductive technologiesdifferentially methylated regionimprinting control regionmonozygotic twinstwinningBECKWITH-WIEDEMANN-SYNDROMENEONATAL DIABETES-MELLITUSIN-VITRO FERTILIZATIONRUSSELL-SILVERCHROMOSOME 11P15PAIR DISCORDANTGENOMEHYPOMETHYLATIONGenetics
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