ackland-epithelialmesenchymal-2007.pdf (458.41 kB)
Epithelial - mesenchymal and mesenchymal - epithelial transitions in carcinoma progression
journal contribution
posted on 2007-11-01, 00:00 authored by H Hugo, Leigh AcklandLeigh Ackland, T Blick, M Lawrence, J Clements, E Williams, E ThompsonLike a set of bookends, cellular, molecular, and genetic changes of the beginnings of life mirror those of one of the most common cause of death--metastatic cancer. Epithelial to mesenchymal transition (EMT) is an important change in cell phenotype which allows the escape of epithelial cells from the structural constraints imposed by tissue architecture, and was first recognized by Elizabeth Hay in the early to mid 1980's to be a central process in early embryonic morphogenesis. Reversals of these changes, termed mesenchymal to epithelial transitions (METs), also occur and are important in tissue construction in normal development. Over the last decade, evidence has mounted for EMT as the means through which solid tissue epithelial cancers invade and metastasize. However, demonstrating this potentially rapid and transient process in vivo has proven difficult and data connecting the relevance of this process to tumor progression is still somewhat limited and controversial. Evidence for an important role of MET in the development of clinically overt metastases is starting to accumulate, and model systems have been developed. This review details recent advances in the knowledge of EMT as it occurs in breast development and carcinoma and prostate cancer progression, and highlights the role that MET plays in cancer metastasis. Finally, perspectives from a clinical and translational viewpoint are discussed.
History
Journal
Journal of cellular physiologyVolume
213Issue
2Pagination
374 - 383Publisher
Alan R. LissLocation
New York, N.Y.Publisher DOI
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ISSN
0021-9541eISSN
1097-4652Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2007, Wiley-LissUsage metrics
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