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Etiology of molar incisor hypomineralization - a systematic review
journal contribution
posted on 2016-08-01, 00:00 authored by Mihiri J Silva, Katrina J Scurrah, Jeffrey CraigJeffrey Craig, David J Manton, Nicky KilpatrickOBJECTIVES: Molar incisor hypomineralization (MIH) is a common developmental dental defect of permanent teeth, which can increase the risk of dental caries, infection and hospitalization. The etiology is currently unclear although prenatal or early childhood health factors are suspected. The aim of this systematic review was to assess the strength of evidence linking etiological factors with MIH. METHODS: A systematic search was conducted using the Medline and Embase electronic databases for studies investigating environmental etiological factors of MIH. Two reviewers assessed the eligibility of studies. The level of evidence and bias was determined for all eligible studies according to Australian National Health and Medical Research Council guidelines for systematic reviews of etiology and the Newcastle-Ottawa Scale. RESULTS: From a total of 2254 studies identified through electronic and hand searching, 28 were eligible for inclusion. Twenty-five of these investigated MIH and three investigated a related condition in primary teeth, hypomineralized second primary molars (HSPM), and these were analysed separately. A limited number of studies reported significant associations between MIH and pre- and perinatal factors such as maternal illness and medication use in pregnancy, prematurity and birth complications. Early childhood illness was implicated as an etiological factor in MIH in several studies, in particular fever, asthma and pneumonia. The studies investigating HSPM revealed an association with maternal alcohol consumption, infantile fever and ethnicity. However, the validity of these findings is impaired by study design, lack of adjustment for confounders, lack of detail and consistency of exposures investigated and poor reporting. CONCLUSIONS: Childhood illness is likely to be associated with MIH. Further prospective studies of the etiology of MIH/HSPM are needed.
History
Journal
Community dentistry and oral epidemiologyVolume
44Issue
4Pagination
342 - 353Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
eISSN
1600-0528Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2016, John Wiley & Sons A/S. Published by John Wiley & Sons LtdUsage metrics
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