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Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
journal contribution
posted on 2017-06-01, 00:00 authored by Soren AlexandersenSoren Alexandersen, Tiffanie Nelson, J Hodge, J DruceWe present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012-2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level. The phylogenetic and network analyses performed support a temporal evolution from the first Australian recombinant virus sequence from November 2013 to March/April 2014, onto the 2015 outbreak. The 2015 outbreak samples fall into two separate clusters with a possible common ancestor between March/April 2014 and September 2015, with each cluster further evolving in the period from September to November/December 2015.
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Journal
Scientific reportsVolume
7Article number
3861Pagination
1 - 12Publisher
Nature Publishing CompanyLocation
London, Eng.Publisher DOI
eISSN
2045-2322Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, The AuthorsUsage metrics
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