shaw-exerciseandglycemic-2017.pdf (3.11 MB)
Exercise and glycemic control: focus on redox homeostasis and redox-sensitive protein signaling
journal contribution
posted on 2017-05-01, 00:00 authored by Lewan ParkerLewan Parker, Chris ShawChris Shaw, N K Stepto, I LevingerPhysical inactivity, excess energy consumption, and obesity are associated with elevated systemic oxidative stress and the sustained activation of redox-sensitive stress-activated protein kinase (SAPK) and mitogen-activated protein kinase signaling pathways. Sustained SAPK activation leads to aberrant insulin signaling, impaired glycemic control, and the development and progression of cardiometabolic disease. Paradoxically, acute exercise transiently increases oxidative stress and SAPK signaling, yet postexercise glycemic control and skeletal muscle function are enhanced. Furthermore, regular exercise leads to the upregulation of antioxidant defense, which likely assists in the mitigation of chronic oxidative stress-associated disease. In this review, we explore the complex spatiotemporal interplay between exercise, oxidative stress, and glycemic control, and highlight exercise-induced reactive oxygen species and redox-sensitive protein signaling as important regulators of glucose homeostasis.
History
Journal
Frontiers in endocrinologyVolume
8Article number
87Pagination
1 - 22Publisher
Frontiers MediaLocation
Lausanne, SwitzerlandPublisher DOI
eISSN
1664-2392Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, Parker, Shaw, Stepto and LevingerUsage metrics
Categories
No categories selectedKeywords
exerciseinsulin signalingstress kinaseglycemic controloxidative stressredoxScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismINSULIN-RECEPTOR SUBSTRATE-1NF-KAPPA-BHUMAN SKELETAL-MUSCLEPOSTPRANDIAL OXIDATIVE STRESSSTIMULATED GLUCOSE-UPTAKEELECTRON-SPIN-RESONANCEHIGH-INTENSITY INTERVALP38 MAP KINASEREACTIVE OXYGENFREE-RADICALS
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC