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Exercise and the skeletal muscle epigenome
journal contribution
posted on 2017-03-20, 00:00 authored by Sean McgeeSean Mcgee, Ken WalderKen WalderAn acute bout of exercise is sufficient to induce changes in skeletal muscle gene expression that are ultimately responsible for the adaptive responses to exercise. Although much research has described the intracellular signaling responses to exercise that are linked to transcriptional regulation, the epigenetic mechanisms involved are only just emerging. This review will provide an overview of epigenetic mechanisms and what is known in the context of exercise. Additionally, we will explore potential interactions between metabolism during exercise and epigenetic regulation, which serves as a framework for potential areas for future research. Finally, we will consider emerging opportunities to pharmacologically manipulate epigenetic regulators and mechanisms to induce aspects of the skeletal muscle exercise adaptive response for therapeutic intervention in various disease states.
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Journal
Cold Spring Harbor Perspectives in MedicineVolume
7Issue
9Publisher
Cold Spring Harbor Laboratory PressLocation
Cold Spring Harbor, N.Y.Publisher DOI
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2157-1422Language
engPublication classification
C1 Refereed article in a scholarly journal; C Journal articleCopyright notice
2017, Cold Spring Harbor Laboratory PressUsage metrics
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