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Exosomes and nanoengineering: a match made for precision therapeutics

journal contribution
posted on 2020-05-01, 00:00 authored by Phuong TranPhuong Tran, Dongxi Xiang, Thao T D Tran, Wang Yin, Yumei Zhang, Lingxue KongLingxue Kong, Kuisheng Chen, Miaomiao Sun, Yong Li, Yingchun Hou, Yimin Zhu, Wei DuanWei Duan
Targeted exosomal delivery systems for precision nanomedicine attract wide interest across areas of molecular cell biology, pharmaceutical sciences, and nanoengineering. Exosomes are naturally derived 50-150 nm nanovesicles that play important roles in cell-to-cell and/or cell-to-tissue communications and cross-species communication. Exosomes are also a promising class of novel drug delivery vehicles owing to their ability to shield their payload from chemical and enzymatic degradations as well as to evade recognition by and subsequent removal by the immune system. Combined with a new class of affinity ligands known as aptamers or chemical antibodies, molecularly targeted exosomes are poised to become the next generation of smartly engineered nanovesicles for precision medicine. Here, recent advances in targeted exosomal delivery systems engineered by aptamer for future strategies to promote human health using this class of human-derived nanovesicles are summarized.

History

Journal

Advanced materials

Volume

32

Issue

18

Article number

1904040

Pagination

1 - 8

Publisher

Wiley

Location

Weinheim, Germany

eISSN

1521-4095

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim