stambas-extracellularmatrix-2021.pdf (881.2 kB)
Extracellular Matrix Enzymes and Immune Cell Biology
journal contribution
posted on 2021-08-01, 00:00 authored by M McMahon, S Ye, Jessie Pedrina, D Dlugolenski, John StambasJohn StambasRemodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease
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Journal
Frontiers in Molecular BiosciencesVolume
8Article number
703868Pagination
1 - 9Publisher
FrontiersLocation
Lausanne, SwitzerlandPublisher DOI
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2296-889XeISSN
2296-889XLanguage
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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a disintegrin and metalloproteinasesa disintegrin and metalloproteinases with thombospondin-1 motifsACUTE LUNG INJURYBINDINGBiochemistry & Molecular Biologyextracellular matrixHEMOPEXIN DOMAINHYALURONANimmunityINTRACELLULAR MATURATIONIN-VIVOLife Sciences & BiomedicinemetalloproteinasesScience & TechnologyT-CELLSTISSUE INHIBITORVERSICAN
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