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Fast-dissolving solid dispersions for the controlled release of poorly watersoluble drugs

journal contribution
posted on 2021-01-01, 00:00 authored by Phuong TranPhuong Tran, B J Lee, T T D Tran


Solid dispersions offer many advantages for oral drug delivery of poorly water-soluble drugs over
other systems, including an increase in drug solubility and drug dissolution. An improvement in drug absorption
and the higher bioavailability of active pharmaceutical ingredients in the gastrointestinal tract have been reported
in various studies. In certain circumstances, a rapid pharmacological effect is required for patients. Fastdissolving
solid dispersions provide an ideal formulation in such cases. This report will provide an overview of
current studies on fast-dissolving solid dispersions, including not only solid dispersion powders with fast dissolution
rates but also specific dose form for the controlled release of poorly water-soluble drugs. Specifically,
the applications of fast-dissolving solid dispersions will be described in every specific case. Moreover, pharmaceutical
approaches and the utilization of polymers will be summarized. The classification and analysis of fastdissolving
solid dispersions could provide insight into strategies and potential applications in future drug delivery
developments.

History

Journal

Current Pharmaceutical Design

Volume

27

Issue

12

Pagination

1498 - 1506

Publisher

Bentham Science Publishers Ltd.

Location

United Arab Emirates

ISSN

1381-6128

eISSN

1873-4286

Language

en

Publication classification

C1 Refereed article in a scholarly journal

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