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Film-Forming Nanogels: Effects of Nanocarriers and Film-Forming Gel on the Sustained Release of Curcumin

journal contribution
posted on 2021-01-01, 00:00 authored by Khanh T Nguyen, Phuong TranPhuong Tran, Hai V Ngo, Thao T D Tran

Background:
Although film-forming hydrogels possess the advantages of both film and
hydrogel dosage forms, certain limitations still remain.


Objective:
This study aims to investigate the
use of film-forming hydrogels and the effects of nanocarriers on the sustained release of a poorly
water-soluble drug, curcumin.


Methods:
The film-forming hydrogels contained either zein or
polyvinylpyrrolidone as a film former, in addition to hydroxypropyl methylcellulose, oleic acid,
ethanol and water. Curcumin was encapsulated in poly(lactic-co-glycolic acid) and gelatine
nanoparticles using a sonoprecipitation method. Free drug and drug-loaded nanoparticles were later
dispersed into blank hydrogels to produce the film-forming nanogels.


Results:
The results suggested
that the encapsulation of curcumin in nanoparticles could reduce the drug particle size to less than
200nm for easier diffusion and could shield curcumin from chemical interactions that limit its topical
permeability. curcumin was more compatible with gelatine nanoparticles than with poly(lactic-coglycolic acid) nanoparticles, and gelatine nanoparticles, in turn, were more compatible with zein than
with polyvinylpyrrolidone film-forming nanogels. Therefore, gelatine nanoparticles in zein filmforming nanogels greatly elevated the permeability of curcumin by over five times that afforded by
gelatine nanoparticles in polyvinylpyrrolidone film-forming nanogels.


Conclusion:
This research
suggested that film-forming nanogel is a promising drug delivery system for both improved
permeability and sustained topical diffusion of the extremely hydrophobic drug curcumin depending
on the compatibility between the nanocarrier and the film-forming hydrogel.

History

Journal

Anti-Cancer Agents in Medicinal Chemistry

Volume

21

Issue

5

Publisher

Bentham Science Publishers Ltd.

Location

San Francisco, Calif.

ISSN

1871-5206

eISSN

1875-5992

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

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