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Fishy business : effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells.
journal contribution
posted on 2014-08-01, 00:00 authored by Damitha De Mel, Cenk SuphiogluCenk SuphiogluOmega-3 (ω-3) fatty acids are one of the two main families of long chain polyunsaturated fatty acids (PUFA). The main omega-3 fatty acids in the mammalian body are α-linolenic acid (ALA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Central nervous tissues of vertebrates are characterized by a high concentration of omega-3 fatty acids. Moreover, in the human brain, DHA is considered as the main structural omega-3 fatty acid, which comprises about 40% of the PUFAs in total. DHA deficiency may be the cause of many disorders such as depression, inability to concentrate, excessive mood swings, anxiety, cardiovascular disease, type 2 diabetes, dry skin and so on. On the other hand, zinc is the most abundant trace metal in the human brain. There are many scientific studies linking zinc, especially excess amounts of free zinc, to cellular death. Neurodegenerative diseases, such as Alzheimer's disease, are characterized by altered zinc metabolism. Both animal model studies and human cell culture studies have shown a possible link between omega-3 fatty acids, zinc transporter levels and free zinc availability at cellular levels. Many other studies have also suggested a possible omega-3 and zinc effect on neurodegeneration and cellular death. Therefore, in this review, we will examine the effect of omega-3 fatty acids on zinc transporters and the importance of free zinc for human neuronal cells. Moreover, we will evaluate the collective understanding of mechanism(s) for the interaction of these elements in neuronal research and their significance for the diagnosis and treatment of neurodegeneration.
History
Journal
NutrientsVolume
6Issue
8Pagination
3245 - 3258Publisher
M D P I AGLocation
Basel, SwitzerlandPublisher DOI
eISSN
2072-6643Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2014, The AuthorsUsage metrics
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Science & TechnologyLife Sciences & BiomedicineNutrition & Dieteticsomega-3 fatty acidsDHAzincZnT3zinc transporterfree zincM17 human neuronal cellsapoptosisPOLYUNSATURATED FATTY-ACIDSPLACEBO-CONTROLLED TRIALDOCOSAHEXAENOIC ACIDALZHEIMERS-DISEASEERYTHROCYTE METALLOTHIONEINCEREBRAL-ISCHEMIACOGNITIVE DECLINECALCIUM CHANNELSAMYLOID PLAQUESTRANSGENIC MICE
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