ward-functional-2022.pdf (2.55 MB)
Functional Analysis of Zebrafish socs4a: Impacts on the Notochord and Sensory Function
journal contribution
posted on 2022-02-10, 00:00 authored by M Trengove, R Wyett, Clifford LiongueClifford Liongue, Alister WardAlister WardThe suppressor of cytokine signaling (SOCS) proteins play important roles in cytokine and growth factor signaling, where they act principally as negative feedback regulators, particularly of the downstream signal transducer and activator of transcription (STAT) transcription factors. This critical mode of regulation impacts on both development and homeostasis. However, understanding of the function of SOCS4 remains limited. To address this, we investigated one of the zebrafish SOCS4 paralogues, socs4a, analyzing its expression and the consequences of its ablation. The socs4a gene had a dynamic expression profile during zebrafish embryogenesis, with initial ubiquitous expression becoming restricted to sensory ganglion within the developing nervous system. The knockdown of zebrafish socs4a revealed novel roles in notochord development, as well as the formation of a functional sensory system.
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Journal
Brain SciencesVolume
12Issue
2Article number
241Pagination
1 - 12Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
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ISSN
2076-3425eISSN
2076-3425Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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