she-functionalizationofhollow-2015.pdf (3.24 MB)
Functionalization of hollow mesoporous silica nanoparticles for improved 5-fu loading
journal contribution
posted on 2015-03-05, 00:00 authored by Xiaodong She, Lijue Chen, Chengpeng Li, C He, Li He, Lingxue KongLingxue Kong© 2015 Xiaodong She et al. Hollow mesoporous silica nanoparticles were successfully fabricated and functionalized with appropriate silanes. After modifications, amine, carboxyl, cyano, and methyl groups were grafted onto the nanoparticles and all functionalized hollow mesoporous silica nanoparticles maintained a spherical and hollow structure with a mean diameter of 120 nm and a shell thickness of 10 nm. The loading capacity of the hollow mesoporous silica nanoaprticles to the anticancer drug, 5-fluorouracil, can be controlled via precise functionalization. The presence of amine groups on the surface of nanoparticles resulted in the highest loading capacity of 28.89%, due to the amine functionalized nanoparticles having a similar hydrophilicity but reverse charge to the drug. In addition, the change in pH leads to the variation of the intensity of electrostatic force between nanoparticles and the drug, which finally affects the loading capacity of amine functionalized hollow mesoporous silica nanoparticles to some extent. Higher drug loading was observed at pH of 7.4 and 8.5 as 5-fluorouracil becomes more deprotonated in alkaline conditions. The improved drug loading capacity by amine functionalized hollow mesoporous silica nanoparticles has demonstrated that they can become potential intracellular 5-fluorouracil delivery vehicles for cancers.
History
Journal
Journal of nanomaterialsVolume
2015Article number
872035Publisher
Hindawi Publishing CorporationLocation
New York, NYPublisher DOI
ISSN
1687-4110eISSN
1687-4129Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, Hindawi Publishing CorporationUsage metrics
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