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HIV-1 vaccine development : tackling virus diversity with a multi-envelope cocktail
journal contribution
posted on 2008-01-01, 00:00 authored by J Hurwitz, X Zhan, S Brown, M Bonsignori, John StambasJohn Stambas, T Lockey, R Sealy, S Surman, P Freiden, B Jones, L Martin, J Blanchard, K SlobodA major obstacle to the design of a global HIV-1 vaccine is viral diversity. At present, data suggest that a vaccine comprising a single antigen will fail to generate broadly reactive B-cell and T-cell responses able to confer protection against the diverse isolates of HIV-1. While some B-cell and T-cell epitopes lie within the more conserved regions of HIV-1 proteins, many are localized to variable regions and differ from one virus to the next. Neutralizing B-cell responses may vary toward viruses with different i) antibody contact residues and/or ii) protein conformations while T-cell responses may vary toward viruses with different (i) T-cell receptor contact residues and/or (ii) amino acid sequences pertinent to antigen processing. Here we review previous and current strategies for HIV-1 vaccine development. We focus on studies at St. Jude Children's Research Hospital (SJCRH) dedicated to the development of an HIV-1 vaccine cocktail strategy. The SJCRH multi-vectored, multi-envelope vaccine has now been shown to elicit HIV-1-specific B- and T-cell functions with a diversity and durability that may be required to prevent HIV-1 infections in humans.
History
Journal
Frontiers in BioscienceVolume
13Issue
2Pagination
609 - 620Publisher
Frontiers in bioscienceLocation
Tampa, U.S.A.Publisher DOI
ISSN
1093-9946eISSN
1093-4715Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2008 Frontiers in BioscienceUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyCell BiologyHIV-1 vaccinemulti-envelope cocktailpreventionnon-human primateclinical trialreviewHUMAN-IMMUNODEFICIENCY-VIRUSNEUTRALIZING ANTIBODY-RESPONSEST-CELLSMALLPOX VACCINATIONTYPE-1 ENVELOPEGAG-POLPASSIVE-IMMUNIZATIONCYNOMOLGUS MONKEYSIMMUNE-RESPONSESDNA VACCINATION
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